Overview

Topologically associating domains (TADs) are contiguous segments of the genome where the genomic elements are in frequent contact with each other. Genes that cooccupy a TAD are often functionally related and more likely to be coexpressed than random gene pairs, The TAD Map (bioRxiv (2021)) provides a consensus estimate, aggregated from multiple experimental datasets, of this layout in human and mouse. It also provides tools to map any single-cell RNA-seq dataset to TAD signatures, where gene expression is mapped to TAD activation probabilities in each cell.

Paper & Code

TAD Map and TAD signatures are described in the preprint TBD (http://doi.org/10.1101/TBD)

Source code available at: https://github.com/rs239/tadmap